Marius Locke Faculty of Physical Education and Health University of Toronto 55 Harbord Street, Room 2021A Toronto, ON M5S 2W6 416-978-7055 marius.locke@utoronto.ca |
Research Associate, Deborah Research Institute, 1995 to 1996
NSERC Postdoctoral Fellow- Deborah Research Institute, Browns Mills, New Jersey 1993-1995
Ph.D. University of Western Ontario, 1993
BSc. University of Western Ontario, 1987
BA. University of Western Ontario, 1984
Summary of Expertise
Cellular response to Exercise, regulation and expression of stress/heat shock proteins in striated muscle, muscle adaptation.
Cells respond to stressful conditions by rapidly synthesizing protective proteins known as Heat Shock Proteins (HSPs) or Stress Proteins (SPs). An elevated expression of HSPs has been shown to provide protection to cells and tissues during episodes of stress. HSPs are known to be involved in numerous processes and are likely to regulate important cell functions. I am currently examining the relationship between HSP expression and the inflammatory transcription factor NF-kB. My work examines the expression and regulation of these proteins in mammalian tissues during episodes of stress such and exercise. I use mammalian models (diabetes, hypertrophy, exercise, heat stress, cold stress, etc) to answer questions regarding the role that HSPs play in various tissues during these times of stress.
Recent Publications
Frier, B. and M. Locke. Heat Stress Inhibits Skeletal Muscle Hypertrophy. Accepted for Publication in Cell Stress and Chaperones, 2007.
Naussbaum, E and M. Locke. Heat Shock Protein Expression in Rat Skeletal Muscle Following Repeated Applications of Pulsed and Continuous Ultrasound. Accepted for publication in Archives of Physical Medicine and Rehabilitation. 2007
Frier, B. and M. Locke. Preservation of heat stress induced myocardial hsp 72 in aged animals following caloric restriction. Experimental Gerontology 40: 615–617, 2005.
Recent Supervised Theses
Eva Najemnikova (MSc) "The Effect of Streptozotocin-Induced Diabetes on Heat Shock Protein Expression in Rat Tissues" 2005.
Scott Driscoll (MSc). "HSP 72 Accumulation in the Rat Hindlimb Following Level and Downhill Running." 2004.
Bruce Charles Frier (MSc) "The Effects of Synergistic Ablation and Heat Shock on the Rat Plantaris Muscle." 2003.
Memberships
American College of Sports Medicine
Canadian Society for Exercise Physiology
International Cell Stress Society